Imagine Marco, a 40-year-old man from Rome. Like many in his age group, he occasionally enjoys a glass of red wine with dinner. Recently, his doctor prescribed him Levitra (vardenafil), a medication used to treat erectile dysfunction (ED). Marco wonders: Is it safe to mix a little wine with this treatment?
This question isn’t unique to Marco. Men across the world face the same concern. To answer it, let’s break down the science in clear, practical terms.

What Levitra Does
Levitra belongs to a class of drugs called PDE5 inhibitors, similar to Viagra and Cialis. Its job is simple but powerful:
- It helps relax blood vessels in the penis.
- This relaxation improves blood flow, making it easier to achieve and maintain an erection.
- It only works when a man is sexually stimulated — it’s not an aphrodisiac.
In short: Levitra boosts the body’s natural response, rather than creating it from scratch.
What Alcohol Does to the Body
Alcohol, especially in larger amounts, affects the cardiovascular system:
- It lowers blood pressure.
- It slows down the central nervous system.
- It may reduce sensitivity and performance in sexual situations.
A small glass of wine may feel relaxing, but heavier drinking can reduce sexual function — the very issue Levitra is meant to solve.
When Alcohol and Levitra Meet
Here’s where the problem starts:
- Both alcohol and Levitra cause vasodilation (widening of blood vessels).
- When combined, this effect can lead to too much blood pressure drop, resulting in dizziness, fainting, headaches, or even heart strain.
- Alcohol also interferes with the effectiveness of Levitra, making erections less reliable.
For Marco, this means that the romantic evening with wine could backfire — the combination may make the medication less effective while also causing unpleasant side effects.
Scientific Evidence
Clinical studies and patient reports suggest:
- Moderate drinking (a glass of wine or beer) is usually safe for most healthy men, but the benefits of Levitra may still be reduced.
- Heavy drinking (multiple glasses or spirits) increases the risks significantly.
- Long-term alcohol use also contributes to chronic erectile dysfunction, making ED medications less useful.
Practical Advice for Men Like Marco

- A small glass of wine with dinner is unlikely to be dangerous, but don’t expect Levitra to work at its best.
- Avoid heavy drinking when planning to use the medication.
- Always follow medical advice — individual health conditions (like high blood pressure or heart disease) may change the risk level.
- When in doubt, it’s safer to skip the alcohol.
Mixing Levitra and alcohol
For a 40-year-old Italian man — or anyone else — mixing Levitra and alcohol is not forbidden, but it’s far from ideal. Levitra is designed to improve sexual performance, while alcohol can undermine it and add risks.
Marco’s best bet? Enjoy his glass of Chianti on another night and keep the focus on intimacy when using Levitra.